Can the Old Antidepressant, Fluvoxamine, Treat COVID-19?

May 13, 2022

Welcome to the informative page dedicated to exploring the potential use of Fluvoxamine, an old antidepressant, in treating COVID-19. As we navigate through the challenges posed by the pandemic, it is crucial to stay informed about potential treatment options that may alleviate the impact of this global health crisis. In this article, we will delve into the mechanisms of Fluvoxamine, assess its effectiveness in combating COVID-19, and examine the latest research and developments surrounding its use.

The Mechanism of Fluvoxamine

Fluvoxamine, known by its trade name Luvox, is a selective serotonin reuptake inhibitor (SSRI) primarily used for the treatment of various mental health conditions, such as depression, obsessive-compulsive disorder (OCD), and anxiety disorders. While traditionally prescribed for its effects on serotonin regulation, recent studies have suggested that Fluvoxamine may possess additional properties that could be beneficial in the context of COVID-19.

Research has indicated that Fluvoxamine may exert anti-inflammatory and immunomodulatory effects, potentially mitigating the cytokine storm commonly associated with severe COVID-19 cases. By modulating the release of certain cytokines and dampening the overactive immune response, it is hypothesized that Fluvoxamine may help prevent the progression of the disease and reduce the severity of symptoms.

Evidence of Effectiveness

Although further research is necessary to establish Fluvoxamine as a definitive treatment for COVID-19, initial clinical trials and observational studies have provided promising results. One notable study conducted at Washington University School of Medicine demonstrated a significant reduction in clinical deterioration among COVID-19 patients treated with Fluvoxamine compared to those receiving a placebo.

Moreover, anecdotal evidence and reports from healthcare professionals suggest that Fluvoxamine may improve the overall well-being and recovery of COVID-19 patients, particularly in cases where respiratory distress and systemic inflammation are prominent features.

Current Research and Developments

Given the potential benefits of Fluvoxamine in COVID-19 management, researchers worldwide have initiated further investigations to ascertain its efficacy and optimal usage. Ongoing trials are exploring the drug's ability to prevent complications in high-risk individuals, its effectiveness in combination with other treatment modalities, and its impact on long-term outcomes.

Additionally, the scientific community is actively evaluating the safety profile of Fluvoxamine, ensuring that its potential benefits outweigh any potential risks or side effects. It is worth noting that, like any medication, Fluvoxamine may interact with other drugs or have contraindications, highlighting the importance of expert medical advice and close monitoring.


In conclusion, while Fluvoxamine as a treatment for COVID-19 is still in the research stage, early findings indicate its potential to be a valuable asset in combatting the effects of the virus. Its anti-inflammatory properties and immunomodulatory effects hold promise for reducing disease severity and preventing complications. As research progresses, it is crucial to stay updated on the latest developments in this field and consult with healthcare professionals for personalized advice.

At Muir Diablo Occupational Medicine, we are dedicated to providing accurate and reliable information to help you navigate the complexities of healthcare decisions. For more information on COVID-19, potential treatments, and preventive measures, feel free to explore our website.

Shashank Dubey
Interesting read! 🌟 Very promising!
Nov 11, 2023